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Updated: Mar 28, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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神経炎症性TNFαは,アストロサイトシグナル伝達によって記憶を損なう

Samia Habbas1, Mirko Santello1, Denise Becker1

  • 1Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland.

Cell
|December 22, 2015
PubMed
まとめ

中枢神経系の炎症時に腫瘍死滅因子α (TNFα) が増加すると,認知機能が低下する. この研究は,TNFαがアストロサイトTNFR1を活性化し,多発性硬化症のモデルにおけるヒポカンパのシナプスと学習を変化させることを明らかにしています.

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Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

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