生殖器内受精治療サイクルにおける生育率
Andrew D A C Smith1,2, Kate Tilling1,2, Scott M Nelson3
1Medical Research Council Integrative Epidemiology Unit at the University of Bristol, UK.
JAMA
|December 31, 2015
まとめ
繰り返し体外受精 (IVF) による生児の確率は高く,6回生後生児の累積率は65. 3%である. これらの発見は,通常限られた3つまたは4つの胚移植を超えて,IVF治療を延長することを支持しています.
科学分野:
- 生殖医学
- 不妊 症 の 治療
- 臨床試験
背景:
- 繰り返し体外受精 (IVF) した生児の割合は十分に確立されていません.
- 現在のIVF治療のプロトコルでは 3~4個の胚移植に 制限されています
研究 の 目的:
- 卵巣刺激によるIVFサイクル毎の生育率を決定する.
- IVFサイクルを繰り返して 生児の累積率を評価する.
主な方法:
- 英国の女性156,947人を対象に257,398回のIVFサイクル (2003年−2010年) を実施した研究.
- 2012年6月までのフォローアップ
- 卵巣刺激と,その後の新鮮/冷凍胚移植として定義されたIVFサイクル.
主要な成果:
- 最初のIVFサイクルでの生育率は29.5%で,第4サイクルでは20%を超えました.
- 予後調整した累積生育率は6週目までに65. 3%に達した.
- 年齢によって割合は大きく変化し,若い女性 (40歳未満) の成功率は高かった.
結論:
- 6回のIVFの後,予後調整した累積生児率は65. 3%であった.
- 3~4サイクル以上のIVF治療の有効性を支持しています.
- 生児出生率は,患者の年齢と特定の治療法によって影響を受けます.
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