腸内皮質の長距離抑制による海馬活動,可塑性,および記憶のゲート化

Jayeeta Basu¹, Jeffrey D Zaremba², Stephanie K Cheung²

¹Department of Neuroscience, Kavli Brain Institute, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA. jayeeta.basu@nyumc.org sas8@columbia.edu.

Science (New York, N.Y.)

|January 9, 2016

まとめ

腸内皮質からの長距離阻害プロジェクションは海馬の神経細胞を無阻害することで記憶の特異性を高めますこのメカニズムは長期記憶の関連付けの精度を高めます

科学分野:

神経科学
記憶に関する研究
メモリの回路

背景:

皮質と海馬の回路は関連記憶の保存に不可欠です
研究は主にヒポカンプスへの刺激性腸内皮質の投影に焦点を当てている.
内側皮質からの阻害的投影の記憶における役割はまだ十分に研究されていない.

研究の目的:

記憶記憶における腸内皮質からの長距離阻害プロジェクションの機能を調査する.
これらの阻害的投影が海馬の活動に及ぼす影響の基礎となる回路レベルのメカニズムを解明する.
これらの投影がメモリエンコーディングの特異性にどのように影響するかを決定する.

主な方法:

ヒポカンプスの電気生理学的記録
神経活動と可塑性の分析
記憶を評価する行動実験

主要な成果:

エントルヒナル皮質からの長距離阻害プロジェクションは文脈やオブジェクト情報に関する記憶の特異性を高めます
これらの投射は,γ-アミノバター酸 (GABA) を放出し,ヒポキャンパスの抑制性ニューロンを標的にします.
この消毒作用は,CA1ピラミッド神経の刺激を一時的に促進し,フィードフォワードの阻害を抑制し,デンドリトスパイクとヘテロシナプス可塑性を促進します.

結論:

腸内皮質からの長距離抑制はヒポカンパスの記憶のエンコーディングを精製する上で重要な役割を果たします
この経路はヒポキャンパスの長期記憶の関連付けの精度を高めます
直接の感覚の入力に関連した情報の大切さを制限することで機能します

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