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RNA Structure01:23

RNA Structure

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RNA Structure01:19

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
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Structural Organization of the Human Body: An Overview01:18

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
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人体ドロシャの構造

S Chul Kwon1, Tuan Anh Nguyen1, Yeon-Gil Choi1

  • 1Center for RNA Research, Institute for Basic Science, Seoul 08826, Korea; School of Biological Sciences, Seoul National University, Seoul 08826, Korea.

Cell
|January 11, 2016
PubMed
まとめ
この要約は機械生成です。

DROSHAとDGCR8で構成されるマイクロプロセッサは,プライマリマイクロRNAを処理する. この研究は,DGCR8に結合したDROSHAのX線構造を明らかにし,マイクロプロセッサの組立とマイクロRNAの成熟を説明しています.

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科学分野:

  • 分子生物学
  • 構造生物学
  • 生物化学

背景:

  • マイクロRNA (miRNA) の生殖は遺伝子調節に不可欠である.
  • RNase III酵素であるDROSHAは,コファクターDGCR8と共にマイクロプロセッサー複合体を形成し,miRNAの成熟を開始する.
  • マイクロプロセッサの構造を理解することは,miRNA処理メカニズムを解明する鍵です.

研究 の 目的:

  • DGCR8との複合体でDROSHAのX線構造を決定する.
  • マイクロプロセッサの組み立ての 分子基礎を解明する
  • DROSHAによるプライマリ miRNA処理の仕組みを理解する.

主な方法:

  • X線結晶学
  • タンパク質複合体の浄化
  • 構造分析

主要な成果:

  • DGCR8のC端のヘリックスと複合したDROSHAのX線構造が決定された.
  • DROSHAは,RNase IIIドメイン (RIIID) に1つずつ2つのDGCR8結合サイトを有し,マイクロプロセッサの組み立てを容易にする.
  • ドロシャはディサーと構造的に類似しており 共通の進化の起源を示唆しています
  • RIIIDの非正規の亜鉛指のモチーフと構造要素を含むDROSHAのユニークな特徴は,その11bpの処理活動を説明します.

結論:

  • この研究は,マイクロプロセッサの組立と機能に関する構造的洞察を提供します.
  • この発見は,ドロシャがディサーの同種から進化したことを示唆している.
  • この研究は,プライマリ miRNA 処理の基礎にある分子メカニズムを解明する.