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Updated: Mar 27, 2026

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola
10:45

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depola

Published on: January 13, 2012

16.5K

陽子ゲートされたCa ((2+) 透過性TRPチャネルは,血栓不全を模倣した状態でミエリンを損傷する

Nicola B Hamilton1, Karolina Kolodziejczyk1, Eleni Kougioumtzidou1

  • 1Department of Neuroscience, Physiology &Pharmacology, University College London, Gower St., London WC1E 6BT, UK.

Nature
|January 14, 2016
PubMed
まとめ

脳内のミエリンに損傷を与えるが,NMDA受容体には影響しない. 代わりに,細胞内酸性の増加はTRPA1チャネルを活性化し,カルシウムレベルを上昇させ,ミエリンを損傷させ,TRPA1を治療標的として示唆する.

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An Ex Vivo Laser-induced Spinal Cord Injury Model to Assess Mechanisms of Axonal Degeneration in Real-time

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
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