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幼児の喘息の遺伝子に対する新しい追加

Marie Godar¹, Bart N Lambrecht²

¹VIB Inflammation Research Center (IRC), Gent University, Zwijnaarde 9052B, Belgium; argenx, Technologiepark 30, 9052 Zwijnaarde, Belgium.

|January 16, 2016

まとめ

喘息感受性遺伝子DENND1Bは,T細胞受容体 (TCR) の内部化を制御することによって,Tヘルパー2 (Th2) 細胞のサイトカイン生成を調節する. この発見は,子供の喘息の発達におけるDENND1Bの役割について分子的な説明を提供します.

科学分野:

免疫学
遺伝学
分子生物学

背景:

幼児期の喘息はTh2免疫反応と遺伝因子に関連しています.
Th2細胞の機能の遺伝的制御を理解することは喘息の研究にとって極めて重要です

研究の目的:

Th2リンパ球機能における喘息感受性遺伝子DENND1Bの役割を調査する.
DENND1BがT細胞受容体 (TCR) 信号伝達に影響する分子メカニズムを解明する.

主な方法:

Th2リンパ球におけるサイトカイン生成の分析
TCRの内部化と内体密輸の規制を調査する.
DENND1Bと喘息の感受性を関連付ける遺伝的研究

主要な成果:

DENND1BはTh2リンパ球におけるサイトカインの産生を制御することが判明した.
この遺伝子はTCRの内部化率と内分細胞へのルーティングを調節する.
これは,DENND1Bと喘息の病原性との間にある分子関連性を示しています.

結論:

DENND1Bは,喘息に関連するTh2細胞の反応を調節する上で重要な役割を果たします.
DENND1BによるTCR内部化の制御は,喘息の病原性における新しい分子機構を提供します.
DENND1Bの機能をターゲットにすることで,小児性喘息の新たな治療戦略が提供される可能性があります.

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