統合失調症
Michael J Owen1, Akira Sawa2, Preben B Mortensen3
1MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Lancet (London, England)
|January 19, 2016
まとめ
統合失調症は 遺伝や環境要因によって 行動や認知に影響される 複雑な脳疾患です 現在の治療法は不十分で 原因と効果的な治療法に関する先進的な研究が 必要とされています
科学分野:
- 神経科学
- 精神科
- 遺伝学
背景:
- 統合失調症は複雑な行動と認知症候群です
- 遺伝や環境要因による 脳の発達障害に起因します
- ドーパミナー神経伝達機能障害は精神病症状に寄与し,他の脳領域も関与しています.
研究 の 目的:
- 統合失調症の複雑さを探るため
- 神経生物学的メカニズムを理解するために
- 治療の分野を特定する
主な方法:
- ゲノミクス,流行病学,神経科学における現在の理解のレビュー.
- ドーパミナーと他の神経回路の関与の分析
- シナプス機能とニューロンの接続性の調査.
主要な成果:
- 統合失調症は 広範囲に広がる脳の領域と 脳の回路の機能不全です
- シナプス障害が ニューロンの接続性の変化の 基礎となる可能性があります
- この 出来事 の 正確 な 性質,場所,時間 は 確か で は あり ませ ん.
結論:
- 統合失調症の理解は学際的な研究によって大きく進歩しています
- より効果的な治療法と サービス提供の改善が不可欠です
- 統合失調症の研究の科学的な進歩には 多くの課題と機会があります
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