Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Channel Rhodopsins01:11

Channel Rhodopsins

3.4K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.4K
Position-effect Variegation02:32

Position-effect Variegation

7.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.3K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.9K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.9K
Epistasis01:39

Epistasis

51.2K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
51.2K
Epistasis Analysis01:09

Epistasis Analysis

6.2K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
6.2K
Genetic Lingo01:11

Genetic Lingo

117.6K
Overview
117.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Coumarin derivatives targeting ergosterol and sphingolipid pathways to inhibit Candida albicans: Molecular, metabolomic, and Drosophila toxicity insights.

Microbial pathogenesis·2026
Same author

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same author

Regulation of reproductive and behavioral plasticity in social insects.

Current opinion in insect science·2026
Same author

A Lineage-Specific Peptide Suppresses Juvenile Hormone to Drive Reproductive and Longevity Reprogramming in Ants.

bioRxiv : the preprint server for biology·2026
Same author

Lipid Metabolic Rewiring During Continuous Prostate Cancer Progression Defines a Biologically Relevant Four-Gene Prognostic Signature.

Biological procedures online·2026
Same author

Effects of positive psychological intervention on psychosocial adjustment in childbearing-age patients with breast cancer.

Frontiers in oncology·2026

関連する実験動画

Updated: Mar 26, 2026

A Rhodopsin Transport Assay by High-Content Imaging Analysis
12:11

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

7.0K

共通のモチーフにおける単基対の差異は,ロドプシン発現の差異を決定する.

Jens Rister1, Ansa Razzaq1, Pamela Boodram1

  • 1Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003-6688, USA.

Science (New York, N.Y.)
|January 20, 2016
PubMed
まとめ

遺伝子調節モチーフの単一の塩基対の変化は,多様な感覚ニューロンサブタイプの進化を可能にします. このメカニズムは特定の光受容体機能の遺伝子発現を微調整し,様々な刺激の検出を可能にします.

さらに関連する動画

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.6K
Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
09:19

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization

Published on: March 16, 2020

7.6K

関連する実験動画

Last Updated: Mar 26, 2026

A Rhodopsin Transport Assay by High-Content Imaging Analysis
12:11

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

7.0K
Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.6K
Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
09:19

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization

Published on: March 16, 2020

7.6K

科学分野:

  • 神経科学
  • 遺伝学
  • 分子生物学

背景:

  • ニューロンのアイデンティティと機能は 末端分化遺伝子によって決定されます
  • 特定のモチーフを持つ 制御領域が これらの遺伝子を制御します
  • 転写因子がインプットを統合する方法を理解することは,細胞型の仕様には極めて重要です.

研究 の 目的:

  • ドロソフィラ・ロドプシンと光伝導遺伝子の制御メカニズムを比較する.
  • 制御シーケンスがトランスクリプションファクタのインプットを統合する方法を調査する.
  • 細胞型特異的な遺伝子発現における特定のモチーフの役割を解明する.

主な方法:

  • ドロソフィラの光受容体遺伝子の制御機構の比較分析
  • 共通の規制動機と異なる規制動機の特定と特徴付け
  • 規制配列における単基対置換の検討

主要な成果:

  • ロドプシンと光伝導遺伝子は11塩基対の活性化モチーフを共有しています.
  • 広く発現する遺伝子は,すべての光受容体において,発現のためのパリンドロミックモチーフを利用する.
  • ロドプシン遺伝子は,サブセット表現のための特定のモチーフを作成する単一塩基対置換を示します.

結論:

  • 感覚ニューロンのサブタイプは,単一のベースペアの変化によって,短い調節モチーフで進化する.
  • これらの変化により,アクティベーターまたはリプレッサーのモチーフが生成されます.
  • このメカニズムは,異なる光受容体のサブセットによって,幅広い刺激の区別を可能にします.