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Updated: Mar 26, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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HOIP/E2~ubiquitin複合体の構造は,RBR E3リガース機構と調節を明らかにする

Bernhard C Lechtenberg1, Akhil Rajput2, Ruslan Sanishvili3

  • 1NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature
|January 21, 2016
PubMed
まとめ

研究者は活性なHOIP RING-between-RING (RBR) E3リガースの構造を明らかにした. この発見は,ユビキチン移転におけるRBR E3リガスのメカニズムを明らかにし,HECTのようなプロセスと新しいユビキチン結合部位を発見した.

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