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Updated: Mar 26, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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トレグ細胞における段階的なFoxo1活性により,腫瘍免疫と自発的自己免疫が区別される

Chong T Luo1,2, Will Liao3, Saida Dadi1

  • 1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Nature
|January 21, 2016
PubMed
まとめ

調節性T (Treg) 細胞は通常自己耐性を維持するが,抗腫瘍免疫を抑制することができる. FOXO1の不活性化は,Treg細胞の移動に不可欠であり,腫瘍の免疫回避を可能にします. Foxo1のシグナリングを操作すると,自己免疫を引き起こすことなく,腫瘍の耐性を破ることができます.

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