関連する実験動画

Updated: Mar 26, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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Ubiquitinated Fancd2は Fan1をゲノム不安定性を防ぐために停止した複製フォークに勧誘する

Christophe Lachaud1, Alberto Moreno2, Francesco Marchesi3

  • 1Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK.

Science (New York, N.Y.)
|January 23, 2016
PubMed
まとめ

ユビキチン化されたFancd2によるFan1核酵素の採用は,ゲノム安定性にとって極めて重要です. このプロセスはDNA複製フォークの停滞中の染色体異常を防止し,DNAインターストランドクロスリンクがない場合でも,Fan1の変異は癌に弱いフェノタイプを引き起こす.

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Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique07:18

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Author Spotlight: Unveiling the Role of SNF2L in Replication Fork Stability and Genome Duplication05:55

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Restarting Stalled Replication Forks02:37

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