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Updated: Mar 26, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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ゲミナルビス (シラン) の独特のステリック効果は,分子間ダイエルス-アルダー反応における高エクソ選択性を制御する

Zengjin Liu1, Xinglong Lin1, Na Yang2

  • 1Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, P. R. China.

Journal of the American Chemical Society
|January 23, 2016
PubMed
まとめ

ゲミナルビス (シラン) [R3Si) 2CH]グループは,高度にエクソセレクティブな分子間ダイエルス-アルダー反応を可能にし,オルト・トランス・サイクロヘキセンを生成する. このステリック制御は,高度な有機合成の大きな可能性を秘めています.

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The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable,...
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