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Updated: Mar 26, 2026

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

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転写因子LRFとBCL11Aは胎児のヘモグロビン発現を独立して抑制する

Takeshi Masuda1, Xin Wang2, Manami Maeda1

  • 1Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|January 28, 2016
PubMed
まとめ

研究者らは,LRF転写因子を成人における胎児のヘモグロビンの静止の鍵として特定しました. この発見は,状細胞病やタラセミアなどのグロービン疾患の治療に新しい治療目標を提供します.

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