中核へのタラミック・インプットはオピエット依存を媒介する
Yingjie Zhu1, Carl F R Wienecke1, Gregory Nachtrab1
1Department of Biology, Stanford University, Stanford, California 94305, USA.
Nature
|February 4, 2016
まとめ
研究者はオピエイト離脱症状に 重要な脳の経路を発見しました タラムスのパラベントリキュラーの中核を nucleus accumbens サーキットにターゲティングすることで オピエット依存症の新たな治療法が提供されるかもしれません
科学分野:
- 神経科学
- 依存症 研究
背景:
- 慢性的なオピエイト使用は依存症と重度の離脱につながる.
- 薬物の報酬と離脱の動機付けに 重要な役割を果たします
- 中核の回路の理解は 極めて重要です
研究 の 目的:
- オピエイト離脱に 関わる脳内経路を特定する
- 離脱症状を媒介するタラマスのパラベントリキュラー核の役割を調査する.
主な方法:
- オピエイト離脱のマウスモデルを使いました
- タラムスのパラベントリキュラー核から 核アキュンベンスの経路を調査した
- オプトジェネティクスを使って 経路の活動を操作した
- シナプス可塑性と受容体の変化を調べた.
主要な成果:
- 核アキュンベンスへのタラムスの入口のパラベントリキュラー核は 物理的な離脱症状と嫌悪を媒介する.
- この経路を静止すると マウスの離脱症状が減った.
- モルフィンは特定のAMPA受容体を通した刺激伝達を増加させた.
- プラスティシティの逆転 抑制された離脱
結論:
- モルヒネが誘発した プラブントリキュラ核の プラブントリキュラ核の プラブントリキュラ核の プラブントリキュラ核の プラブントリキュラ核の プラブントリキュラ核の
- この回路を再プログラムすれば オピエイト依存症の治療に 役立つ可能性がある
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