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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds
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プラズモディアム選択性プロテアソーム阻害剤の構造と機能に基づく設計

Hao Li1,2, Anthony J O'Donoghue3, Wouter A van der Linden1

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

Nature
|February 12, 2016
PubMed
まとめ

研究者はマラリア治療のために 選択性プロテアソーム阻害剤を開発しました これらの化合物はプラズモディウムプロテアソームを標的とし,薬剤耐性寄生虫に対する有効性を示し,宿主に対する毒性が最小限であり,有望な新しい抗マラリア戦略を提供します.

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