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関連する概念動画

Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

7.4K
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
7.4K
Spare Receptors01:30

Spare Receptors

4.8K
Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
4.8K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

33.0K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
33.0K
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

37.7K
Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...
37.7K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

19.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
19.5K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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関連する実験動画

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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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あらゆる 機会 に 応える 方

Darrell J Irvine1

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Department of Materials Science & Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; The Ragon Institute of MGH, Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, Massachusetts 02139, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

Cell
|February 13, 2016
PubMed
まとめ
この要約は機械生成です。

科学者は合成ノッチ受容体を設計し 細胞の信号伝達を制御しました この突破は 細胞のインプットとアウトプットの 独立した管理を可能にします

さらに関連する動画

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy

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High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
15:13

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy

Published on: July 25, 2014

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関連する実験動画

Last Updated: Mar 25, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
10:24

Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy

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High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
15:13

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科学分野:

  • 細胞生物学
  • 合成生物学
  • バイオテクノロジー

背景:

  • 細胞表面受容体は細胞と環境の間のコミュニケーションを媒介する.
  • 自然な細胞経路から独立して制御可能なインプットとアウトプットを持つ受容体を設計することは依然として大きな課題です.

研究 の 目的:

  • 細胞表面受容体を設計する 新しいシステムを開発する
  • エンジニアリングされた受容体の入力と出力の両方に独立した制御を達成します.

主な方法:

  • 合成のノッチ受容体を基として使った.
  • 様々な種類の細胞でシステムの機能性を実証した.

主要な成果:

  • 受容器の入力と出力の独立した制御を可能にするシステムを成功裏に作成しました.
  • エンジニアリングされた受容体は内生的な信号伝達経路に直角的に機能します

結論:

  • 開発された合成ノッチ受容体は 細胞機能を正確に制御するための強力なツールです
  • この技術は 細胞ベースの治療法や 合成生物学の応用に広範囲に及ぶものです