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Updated: Mar 25, 2026

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
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An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

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Myc 枯渇は,ダイアパウスを模倣する多能性の休眠状態を誘発する

Roberta Scognamiglio1, Nina Cabezas-Wallscheid1, Marc Christian Thier1

  • 1Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Cell
|February 13, 2016
PubMed
まとめ

Mycは幹細胞の休眠状態を制御する. マウスの胚性幹細胞におけるMycの減少は,増殖とタンパク質の合成を停止し,胚性ダイアパウスのような可逆的な休眠状態を誘発し,多能性に影響を与えない.

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