アンフィフィリック円筒型トライブロックコミセルの階層的な組み立てによる"クロス"スーパミセル
Xiaoyu Li1, Yang Gao1, Charlotte E Boott1
1School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.
Journal of the American Chemical Society
|February 16, 2016
まとめ
研究者らは,アンフィフィリックトライブロックコミセルを使用して,合成"クロス"スーパーミセルを作成しました. 断片の長さと溶媒の相互作用を調整することで 精密に組み立てられ これらの複雑な構造の予測可能な形成を可能にしました
科学分野:
- ポリマー化学
- 超分子化学
- 材料科学
背景:
- 生物学的なシステムは,染色体のような複雑な自己組み立ての"クロス"アーキテクチャを示しています.
- これらの生物学的構造の合成類は極めて稀で,材料科学では大きな課題となっています.
研究 の 目的:
- P-H-Pトライブロックコミセルの階層的組成を調査する.
- 制御された条件下で合成"クロス"スーパーミセルの形成を達成する.
- 超ミセルの形成を予測するための相図を確立する.
主な方法:
- よく定義されたP-H-Pトライブロックコミセルを合成するために,生結晶駆動セルフアセンブリ (CDSA) を利用した.
- ハイドロフォビック (H) セグメントの長さ (L1) とコロナ (P) チェーンの長さ (L2) を制御します.
- レーザースキャンコンフォカル顕微鏡 (LSCM),伝送電子顕微鏡 (TEM),ダイナミック光散射 (DLS) を用いた.
主要な成果:
- 交差点エネルギーと冠状ステリック効果を調節することで"交差点"スーパーミセルを成功裏に形成した.
- アセンブリパラメータに基づいて"クロス"スーパーミケルの独占的形成を予測する相図を開発した.
- 溶液中の動力的に安定した マイクロンサイズのコロイド的に安定した "クロス" 超微粒子の存在が確認されました
結論:
- 複雑な"クロス"超細胞構造の制御された合成の方法を示した.
- 確立された相図は,同様のトライブロックコミセルを設計するための予測ツールを提供します.
- これらの合成の"交差"超微生物は 生物の自己組織化を模倣する上で 重要な進歩を示しています
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