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Updated: May 14, 2026

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model
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Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

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血管細胞粘着分子1の直接発現クローニング,これはリンパ球に結合するサイトカイン誘発性内皮タンパク質で,リンパ球に結合する

L Osborn1, C Hession, R Tizard

  • 1Biogen, Inc., Cambridge Center, Massachusetts 02142.

Cell
|December 22, 1989
PubMed
まとめ

研究者は,リンパ球に結合する内皮細胞にシトカイン誘発された新しい粘着分子である血管細胞粘着分子-1 (VCAM-1) を特定しました. この分子は,炎症部位への単核白血球の徴募において重要な役割を果たします.

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Author Spotlight: Unveiling the Potential of Unpurified Recombinant AAVs in Cell Culture Research06:41

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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...