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Updated: Mar 25, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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CRL4 (CRBN) ユビキチンリガゼによるレナリドミド誘発CK1α分解の構造的基礎

Georg Petzold1,2, Eric S Fischer1,2, Nicolas H Thomä1,2

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Nature
|February 25, 2016
PubMed
まとめ

レナリドミドは免疫調節薬 (IMiD) で,CRL4 (CRBN) E3ユビキチンリガスを再利用して,CK1αのようなタンパク質を分解する. このメカニズムは,レナリドミドの

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