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MTAP/CDKN2Aが削除されたがんにおけるメチオニンの代謝障害は,PRMT5への依存につながります

Konstantinos J Mavrakis1, E Robert McDonald1, Michael R Schlabach1

  • 1Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

Science (New York, N.Y.)
|February 26, 2016
PubMed
まとめ

MTAPが削除されたがんはMTAを蓄積し,PRMT5を阻害する. これはPRMT5阻害に対する脆弱性を生み出し,これらの腫瘍に対する潜在的な治療としてPRMT5阻害剤を示唆している.

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