栄養不良の子どもの微生物群に伝染する成長障害を防ぐ腸内細菌
Laura V Blanton1, Mark R Charbonneau1, Tarek Salih1
1Center for Genome Sciences and Systems Biology and Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA.
Science (New York, N.Y.)
|February 26, 2016
まとめ
栄養不良の子供には 成長を阻む未熟な腸内細菌群があります 健康な微生物群や特定の細菌を 栄養不良のマウスに導入すると 健康な成長と代謝が回復し 微生物群の不成熟が 栄養不良を引き起こすことを示唆しています
科学分野:
- 微生物学
- 人間 の 栄養
- 発達生物学
背景:
- 子どもの栄養不良は 世界的な健康問題です
- 腸内微生物群は 子どもの発達と健康に 重要な役割を果たします
- 栄養不良の子供では腸内微生物群の発達障害が観察されています.
研究 の 目的:
- 腸内微生物群の不成熟が 子どもの栄養失調に及ぼす因果関係を調べる
- 栄養不足に対する腸内微生物群の潜在的治療標的を特定する.
主な方法:
- マラウィの栄養不足の健康なドナーの腸内微生物を マラウィの食事で食べた 細菌のないマウスに移植しました
- 腸内微生物分類と宿主現象型 (成長,代謝,骨形態) の相関を分析する.
- コハウジングと特定の細菌種 (Ruminococcus gnavus,Clostridium symbiosum) が受容マウスに与える影響を評価する.
主要な成果:
- 栄養不良のドナーからの不成熟の腸内微生物群は 成長障害のフェノタイプを 受給マウスに伝達した.
- ホストの痩身量,代謝,骨の形状に相関する年齢と成長を差別する特定の微生物分類.
- 健康な微生物群と併用したり,Ruminococcus gnavusとClostridium symbiosumを導入したりすると,受容マウスの成長と代謝異常が改善された.
結論:
- 微生物群の不成熟は 子どもの栄養不良と因果関係があります
- 特定の腸内細菌は 栄養不良の治療における 潜在的治療目標です
- 健康な腸内微生物の組成を回復することで 栄養不良に関連した表型を逆転させることができます
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