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Updated: Mar 25, 2026

Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and Recombination
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Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and Recombination

Published on: July 18, 2025

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DNAトポイソメラーゼVIのような複合体は,メオティック再結合を開始する

Nathalie Vrielynck1, Aurélie Chambon1, Daniel Vezon1

  • 1Institut Jean-Pierre Bourgin (IJPB), INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.

Science (New York, N.Y.)
|February 27, 2016
PubMed
まとめ

研究者らは,メイオシス中のDNA二重鎖破裂 (DSB) 形成に不可欠な新しいタンパク質であるメイオシストポイソメラーゼVIB (MTOPVIB) を特定しました. この発見は,真核性ミオティックDSB機構が古代トポイソメラーゼVIと構造を共有することを示唆している.

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