関連する実験動画
Updated: Mar 25, 2026

10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
36.7K
救急医:命と死の問題?
1Sheikh Ahmed Pancreatic Cancer Research Center, Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston, TX 77030, USA.
Cell
|February 27, 2016
まとめ
トランスフォーミング・成長因子β (TGF-β) は,がんにおいて二重の役割を果たします. この研究は,TGF-β誘発の上皮細胞-メゼンキーマ移行 (EMT) が,臓がんにおけるアポトーシスまたは腫瘍の進行をどのように導いているかを明らかにしています.
科学分野:
- 腫瘍学
- 分子生物学
- 細胞生物学
背景:
- 変形成長因子β (TGF-β) は,がんにおける文脈依存的な役割を持つプレオトロプ的サイトカインである.
- TGF-βは抗腫瘍性またはプロ腫瘍性因子として作用し,がんの進行に影響を与える.
- 癌の転移における重要なプロセスであり,しばしばTGF-βによって調節される.
研究 の 目的:
- TGF-β誘発のEMTがアポトーシスまたは腫瘍の進行にどのように結びついているかについてのメカニズム的根拠を解明する.
- 臓がんにおけるTGF-βの文脈依存的機能を調査する.
- ガンにおける細胞運命を決定するTGF-β信号を結びつける分子経路を理解する.
主な方法:
- 臓がんのマウスモデルを使用しました
- EMTに対するTGF-βシグナルの効果を分析した.
- アポトーシスと腫瘍の進行を含む,TGF-β誘発のEMTのダウンストリーム結果を調査した.
主要な成果:
- TGF-β誘発のEMTが臓がんにおける細胞運命を決定する特定のメカニズムを特定した.
- TGF-βシグナル伝達 (アポプトーシス vs. 進行) の結果は,腫瘍の微小環境または細胞環境に依存することを実証した.
- TGF-βの抗腫瘍効果とプロ腫瘍効果の切り替えを媒介する重要な分子作用者が発見されました.
結論:
- 臓がんにおけるTGF-βの役割は高度に文脈に依存し,EMTの結果に影響します.
- これらのメカニズムを理解することは 標的治療の開発に不可欠です
- この研究は,TGF-βとEMTとがんの進行の複雑な相互作用に関する新しい洞察を提供します.
関連する概念動画
Metastasis
6.8K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.8K
Cadherins in Tissue Organization
4.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
4.5K
Mesenchymal Stem Cells
6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.0K
The Extracellular Matrix
13.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.1K
The Extracellular Matrix
91.0K
Overview
91.0K
Cell Migration
7.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.3K

