地上管制からトム少佐へ

Wendy M Knowlton¹, Yishi Jin²

¹Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.

Cell

|February 27, 2016

まとめ

細胞体からの信号が必要です局所的な軸索だけでなくこの研究では,細胞が体から発する信号に対して,プロアポプトティックなタンパク質であるPumaが決定的な役割を果たしていることが判明した.

科学分野:

神経科学
細胞生物学
分子生物学

背景:

アクソン退化は伝統的に局所的なプロセスとして見なされていた.
ニューロンの細胞体が軸索の退化に重要な役割を果たしていることが示唆されています
細胞体から発する特定の信号はほとんど不明である.

研究の目的:

細胞体が軸索の退化を引き起こす役割を調査する.
アクソン変性を引き起こす細胞体からの信号に関与する重要な分子因子を特定する.

主な方法:

トロフィック剥奪の細胞培養モデルを用いて,アクソン退化を引き起こした.
タンパク質の発現と機能を分析するために分子生物学技術を用いた.
変性経路におけるプロアポプトシスタンパク質の役割を調査した.

主要な成果:

アクソン変性だけが局所的な出来事ではなく,細胞体の関与が必要であることを示した.
細胞体からの信号の重要な媒介体としてプロアポプトティックタンパク質 Puma を特定した.
アクソン退化につながるプログラムにおける PUMAの重要な役割を示した.

結論:

細胞体はアクティブにアクソン変性に参加し信号を送ります
細胞体が軸索の退化に寄与する重要な分子です
この経路を理解すると神経変性疾患の新たな治療目標が生まれます

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