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Updated: Feb 12, 2026

Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor
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Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor

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RQC装置の故障はタンパク質の集積とタンパク質毒性ストレスを引き起こす

Young-Jun Choe1, Sae-Hun Park1, Timm Hassemer1

  • 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

Nature
|March 3, 2016
PubMed
まとめ

リボソームの停滞は ストップコドンが欠けることで タンパク質の集積と神経変性が生じます リボソーム品質管理 (RQC) 機構は通常これを防ぐが,その障害はタンパク質のホメオスタシスを破壊する.

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