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クローナルネオアンチゲンはT細胞の免疫反応と免疫チェックポイントの阻害に対する感受性を誘発する

Nicholas McGranahan1, Andrew J S Furness2, Rachel Rosenthal3

  • 1The Francis Crick Institute, London WC2A 3LY, UK. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London (UCL), London WC1E 6BT, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK.

Science (New York, N.Y.)
|March 5, 2016
PubMed
まとめ

腫瘍新抗原の異質性は免疫反応に影響する. 肺がんやメラノーマの免疫チェックポイント阻害剤の有効性を改善する可能性がある.

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