関連する実験動画

Updated: Mar 24, 2026

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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DNA損傷反応のストキャスティックな活性化により,細胞間での突然変異率の変動が生じます

Stephan Uphoff1, Nathan D Lord2, Burak Okumus2

  • 1Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. stephan.uphoff@bioch.ox.ac.uk johan_paulsson@harvard.edu.

Science (New York, N.Y.)
|March 5, 2016
PubMed
まとめ

大腸菌の遺伝子発現騒音は 予測不能なタンパク質レベルを引き起こし,DNA修復を遅らせ,突然変異率を高めます 細胞は 有害なタンパク質の蓄積のリスクと 効果的な修復をバランスとします

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