非対称ペプチド双層膜の設計

Sha Li^1,2, Anil K Mehta^1,2, Anton N Sidorov^1,2

¹Departments of Biology and Chemistry, ‡Emory NMR Center, ⊥Emory Integrated Cellular Imaging Core, Emory University , Atlanta, Georgia 30322, United States.

Journal of the American Chemical Society

|March 5, 2016

まとめ

研究者はクロス-βアセンブリを制御して堅固な非対称ペプチド膜を設計した. これらのペプチドナノチューブにはパターン付きの電荷格子があり,高度な機能的な材料のために異なる内外面を作り出します

科学分野:

バイオマテリアル科学
超分子化学
ナノテクノロジー

背景:

ペプチドクロスβアセンブリは,自己アセンブリ機能ナノマテリアルのために不可欠です.
これらのアセンブリの構造的基礎を理解することは,新しいペプチドベースのシステムの設計に鍵となります.
不対称な膜は,様々な用途にユニークな特性を提供します.

研究の目的:

頑丈な非対称な二層ペプチド膜を設計し,構築する.
異なるN末端の残基を持つペプチドの自己組み立てを研究する.
機能的なメソスケール構造のためのペプチドアセンブリに対するアーキテクチャ制御を達成する.

主な方法:

ペプチドクロスβ組の構造的特徴
2つのペプチドの共同組成で,N末端の残留物 (リンチリンとリンチリン) が異なっている.
制御された充電格子とフラフレット組成でナノチューブを形成する.

主要な成果:

パターン付き充電格子を持つ非対称な二層ペプチド膜を成功裏に構築した.
負の外面と正の内面を持つナノチューブを形成する,均質なまたは混合されたフラフレット組成が得られる.
ナノチューブの長さに沿った構造制御をクロスシッディング技術で実証した.

結論:

クロスβアセンブリに対するアーキテクチャ制御は,高度に秩序付けられた非対称な膜の作成を可能にします.
これらのペプチドナノチューブは,機能的なメソスケールアセンブリを構築するためのプラットフォームとして機能します.
充電された格子とナノチューブ構造の精密な制御は材料科学の新たな道を開きます

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