脊髄阻害性インターニューロン多様性は,変異性運動マイクロ回路を図示する

Jay B Bikoff¹, Mariano I Gabitto¹, Andre F Rivard²

¹Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA; Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

Cell

|March 8, 2016

まとめ

運動に不可欠な脊髄内ニューロンは多様です研究者は遺伝子発現に基づいて,異なるV1インターニューロンサブセットを特定し,異なる肢体筋肉の微回路組織を明らかにしました.

科学分野:

神経科学
モーターコントロール
細胞生物学

背景:

脊髄回路は精密な筋肉の活性化によって動物の動きを制御します
局所的な内ニューロンはこれらの回路の鍵ですが,その多様性と組織は完全に理解されていません.

研究の目的:

運動制御における主要な抑制集団であるV1内ニューロンの多様性と組織的論理を調査する.
V1インターニューロンのサブセットが異なる性質と空間分布を持っているかどうかを判断する.

主な方法:

V1 内ニューロンにおける転写因子発現の分析.
特定されたV1インターニューロンサブセットの生理学的性質と空間的分布の特徴づけ.

主要な成果:

V1内ニューロンは,19の転写因子に基づいて,様々なサブセットに分割される.
これらの転写的に定義されたサブセットは,異なる生理学的なサインと空間的バイアス (中側,背中) を示しています.
位置の違いは感覚と運動ニューロンの入力に影響し位置がマイクロ回路の組織を決定することを示唆しています

結論:

内神経の位置は脊髄のマイクロ回路の組織を決定する重要な要素です
V1内部ニューロンの多様性は,異なる肢体筋肉プール (股関節,足) のための可変抑制マイクロ回路アーキテクチャを意味します.
手足の動きを制御する柔軟な回路の設計を明らかにしています

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