プラチナベースの化学療法による治療後に進行した局所的に進行したおよび転移した尿路癌の患者におけるアテゾリズマブ:

Jonathan E Rosenberg ¹, Jean Hoffman-Censits ², Tom Powles ³

¹Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
²Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA, USA.
³Barts Cancer Institute ECMC, Barts Health and the Royal Free NHS Trust, Queen Mary University of London, London, UK.
⁴Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands.
⁵Genitourinary Cancers Program, Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, USA.
⁶Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁷Medstar Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington, DC, USA.
⁸Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
⁹The Angeles Clinic and Research Institute, Los Angeles, CA, USA.
¹⁰Department of Cancer Medicine, Gustave-Roussy Cancer Campus, Villejuif, University of Paris Sud, Paris, France.
¹¹Division of Oncology/Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
¹²Department of Urology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
¹³Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
¹⁴Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA.
¹⁵Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA.
¹⁶Virginia Oncology Associates, US Oncology Research, Norfolk, VA, USA.
¹⁷Smilow Cancer Center, Yale University, New Haven, CT, USA.
¹⁸Department of Oncology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Navarre, Spain.
¹⁹Sarah Cannon Research Institute, Nashville, TN, USA; Tennessee Oncology, Nashville, TN, USA.
²⁰Medical Oncology Department, Genitourinary Oncology Unit, University Hospital 12 de Octubre, Madrid, Spain.
²¹Division of Medical Oncology, Department of Medicine, University of Ottawa, The Ottawa Hospital Research Institute, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
²²Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
²³Genentech Inc, 1 DNA Way, South San Francisco, CA, USA.
²⁴Foundation Medicine Inc, Cambridge, MA, USA.
²⁵Division of Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.

⁰Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

まとめ

アテゾリズマブは,転移性泌尿器がんの患者で持続的な活性を示し,過去対照と比較して改善された応答率を示した. プログラム死亡リガンド1 (PD- L1) 発現の上昇は,治療効果の上昇と相関する.

プラチナベースの化学療法による治療後に進行した局所的に進行したおよび転移した尿路癌の患者におけるアテゾリズマブ:

まとめ

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背景

研究の目的

主な方法

主要な成果

結論

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プラチナベースの化学療法による治療後に進行した局所的に進行したおよび転移した尿路癌の患者におけるアテゾリズマブ:

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まとめ

科学分野

背景

研究 の 目的

主な方法

主要な成果

結論

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研究の目的

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