アニオンリレー化学 (ARC) を利用する (-) マンデレリドAの総合成:II型ARC/CuCNクロスカップリングプロトコルの識別

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Updated: Mar 24, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

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Minh H Nguyen1, Masashi Imanishi1, Taichi Kurogi1

  • 1Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

Journal of the American Chemical Society
|March 9, 2016
PubMed
まとめ

アニオンリレー化学 (ARC) は,細胞毒性海洋マクロリド (-) - マンデラリドAの完全な合成を可能にしました. この多成分結合戦術は 複雑な分子断片を 単純な構成要素から 高度にステレオ化学的制御で 素早く組み立てました

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Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
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