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キナーゼ阻害剤がゲートキーパー残基変異にどう抵抗するか

Jagannath Mondal1, Pratyush Tiwary2, B J Berne2

  • 1Tata Institute of Fundamental Research, Center for Interdisciplinary Sciences, Hyderabad, India.

Journal of the American Chemical Society
|March 9, 2016
PubMed
まとめ

ゲートキーパー変異は 癌の薬剤耐性を引き起こします この研究は,より良い薬剤設計のための高度なシミュレーションを使用して,II型阻害剤RL45が抵抗を克服し,I型阻害剤ダサチニブが失敗する理由を示しています.

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