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アミロイド-βとα-シヌクレインは,ラジカル・スキャベリングとレドックス・サイレンシングにより,金属触媒反応性酸素種レベルを低下させる

Jeppe T Pedersen, Serene W Chen1, Christian B Borg2

  • 1Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

Journal of the American Chemical Society
|March 12, 2016
PubMed
まとめ

反応性酸素種 (ROS) の形成は,アミロイドベータ (Aβ) とアルファシヌクレイン (αS) が銅に結合することで減少する. これは,集合ペプチドが直接ROSを増加させるのではなく,金属イオンを集中させ,神経変性疾患の経路に影響を与える可能性があることを示唆しています.

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