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Updated: Mar 24, 2026

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

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CASTORタンパク質はmTORC1経路のアルギニンセンサーである

Lynne Chantranupong1, Sonia M Scaria1, Robert A Saxton1

  • 1Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge MA 02142, USA.

Cell
|March 15, 2016
PubMed
まとめ

CASTOR1は新しいアルギニンセンサーとして作用し,mTORC1経路を調節するためにGATOR2と相互作用します. この発見により アルギニンの欠乏が 細胞の成長シグナル伝達を 阻害する仕組みが明らかになりました

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