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PGC1αは,酸化代謝と腎臓の保護を結びつけるNAD生物合成を誘導する

Mei T Tran1,2, Zsuzsanna K Zsengeller1,2,3, Anders H Berg3,4

  • 1Division of Nephrology and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|March 17, 2016
PubMed
まとめ

ミトコンドリアの調節体であるPGC1αは,ニコチナミドアデニン・ディヌクレオチド (NAD) の生成を制御することによって,損傷後の腎臓の回復に不可欠です. ナイアシナミド (NAM) のサプリメントはNADレベルを回復し,PGC1αが欠けているマウスの腎機能を改善します.

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