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Updated: Mar 24, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

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アミノ酸センサGCN2は,炎症体活性化を抑制することによって,腸内炎症を制御する

Rajesh Ravindran1, Jens Loebbermann1, Helder I Nakaya2

  • 1Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.

Nature
|March 17, 2016
PubMed
まとめ

一般的に抑制されない (GCN2) キナーゼは,炎症体の活性化を抑制することによって,アミノ酸の飢餓を感知して腸内炎症を制御する. GCN2欠乏症は,減少した自己消化,増加したROS,およびIL- 1βの産生によって炎症を増加させる.

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