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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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コレステロール代謝を調節することによってCD8 ((+) T細胞の抗腫瘍反応を強める

Wei Yang1, Yibing Bai1, Ying Xiong2

  • 1State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Nature
|March 17, 2016
PubMed
まとめ

CD8 ((+)) T細胞のコレステロールエステル化を阻害することで,その抗がん活性が強化される. このアプローチはACAT1阻害を用いて T細胞の機能を増強することで 癌の免疫療法に希望を示しています

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