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B型肝炎ウイルスのXタンパク質は,宿主制限因子としてSmc5/6複合体を識別する

Adrien Decorsière1, Henrik Mueller1, Pieter C van Breugel1

  • 1Department of Microbiology and Molecular Medicine, University Medical Centre (C.M.U.), Rue Michel-Servet 1, 1211 Geneva 4, Switzerland.

Nature
|March 18, 2016
PubMed
まとめ

B型肝炎ウイルスのタンパク質HBxは,ウイルスのDNA転写を阻害する細胞因子であるSmc5 / 6複合体を分解します. この分解によりウイルスが複製され 慢性B型肝炎の治療対象となるのです

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