母親の微生物群は,産後早期の先天性免疫発達を促す
Mercedes Gomez de Agüero1, Stephanie C Ganal-Vonarburg1, Tobias Fuhrer2
1Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland.
Science (New York, N.Y.)
|March 19, 2016
まとめ
妊娠中の母親の微生物は 子孫の免疫を形作ります 乳児の微生物の処理能力が向上し 腸内細菌の侵入を防ぐことで 免疫発達における 母親の微生物群の重要性を強調しています
科学分野:
- 免疫学
- 微生物群の研究
- 発達生物学
背景:
- 産後微生物のコロニー化は 免疫系の発達を促すと考えられています
- 妊娠中の母親の微生物群が 子孫の免疫形成に果たす役割は まだ十分に理解されていない.
研究 の 目的:
- 妊娠中の母親の微生物群が 子孫の免疫系の発達に どう影響するか調べる
- 妊娠中の微生物被曝の影響を受けた特定の免疫細胞と分子経路を特定する.
主な方法:
- 特定の微生物で 妊娠したマウスを kolonized.
- 子孫の免疫細胞集団 (例えば,先天性リンパ性細胞,単核細胞) を分析した.
- 子犬の腸内転写プロファイルと遺伝子発現を調べた.
- これらの効果を媒介する母親の抗体の役割を調査した.
主要な成果:
- 妊娠期のコロニゼーションは,子犬の腸内グループ3の先天性リンパ性細胞とF4/ 80 ((+) CD11c ((+)) の単核細胞を増加させた.
- 母親の微生物群は 子孫の腸内遺伝子発現を再プログラムし 抗菌ペプチドと微生物の代謝経路を強化しました
- これらの効果は部分的に母から子孫に伝染する抗体に依存していた.
- 植民された母親の子孫は 微生物分子に対する炎症反応が減り 微生物の侵入に対する抵抗性が向上しました
結論:
- 母親の微生物群は 妊娠中に 子孫の免疫系をプログラムする上で 重要な役割を果たします
- 妊娠中の微生物への曝露は,潜在的に母親の抗体を通して,子孫の免疫耐性を高め,バリア機能を高めます.
- この研究は,母親の微生物群が 子孫の免疫健康に及ぼす 世代を超えた影響を強調しています
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