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Updated: Mar 14, 2026

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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Kv3.3チャンネルは,チャンネルゲージを制御する安定したローカルアクチンネットワークを組み立てるためにHax-1とArp2/3を結合します

Yalan Zhang1, Xiao-Feng Zhang2, Matthew R Fleming1

  • 1Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520.

Cell
|March 22, 2016
PubMed
まとめ

Kv3. 3のカリウムチャネルは,アクチン細胞骨格のダイナミクスをHax-1経由で調節し,迅速なチャネル不活性化とニューロンの健康を予防するために重要である. この相互作用を阻害する突然変異は神経変異を引き起こす.

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