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Updated: Mar 23, 2026

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

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β-アレスティン2の形状シグネチャーは,そのトラフィックとシグナリング機能を予測する

Mi-Hye Lee1, Kathryn M Appleton1, Erik G Strungs1

  • 1Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Nature
|March 24, 2016
PubMed
まとめ

アレスティンは,Gタンパク質結合受容体 (GPCRs) の主要な調節体である. この研究は,リガンド受容体の情報をコードする,下流の信号伝達に影響を与える,明確なアリストリン形状のサインを明らかにする.

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Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin13:45

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