関連する実験動画

Updated: Mar 23, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
06:38

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

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人間 の 転写 因子 の 変化 を 調査 する と,DNA の 結合 度 が 変化 し て いる こと が 明らか に なり ます

Luis A Barrera1,2,3,4, Anastasia Vedenko1, Jesse V Kurland1

  • 1Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|March 26, 2016
PubMed
まとめ

ほとんどの人は遺伝的変異により独特の転写因子 (TF) DNA結合活動を持っています. この研究は,TFの変種を調査した.

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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