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Updated: Mar 23, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

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ゲルムラインを標的とする免疫原によって明らかにされたHIV-1の広範な中和性抗体前駆体B細胞

Joseph G Jardine1, Daniel W Kulp1, Colin Havenar-Daughton2

  • 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|March 26, 2016
PubMed
まとめ

研究者らは,有効なHIVワクチンの広範な中和抗体 (bnAbs) の生成を開始する新しい生殖線標的免疫原 (eOD-GT8) を開発した. この免疫原はヒトにおける前駆体B細胞を成功裏に特定し,ワクチン候補としてその可能性を裏付けました.

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Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production08:22

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