関連する実験動画

Updated: Mar 23, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

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AgRPニューロンは,ブラウン脂肪組織におけるミオスタチン発現を通じて全身インスリン感受性を制御する

Sophie M Steculorum1, Johan Ruud1, Ismene Karakasilioti1

  • 1Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.

Cell
|March 26, 2016
PubMed
まとめ

Agouti関連ペプチド (AgRP) ニューロンを活性化すると,茶色脂肪を再プログラムすることで,栄養とインスリン抵抗性を誘発します. ミオスタチンをターゲットにすると インスリン感受性が改善され, 飢えとグルコースのコントロールの関係が明らかになる.

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