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Updated: Mar 23, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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COP9シグナルソームによるCullin-RINGユビキチンE3リガゼの調節

Simone Cavadini1,2, Eric S Fischer1,2,3,4, Richard D Bunker1,2

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

Nature
|April 1, 2016
PubMed
まとめ

COP9シグナルソーム複合体 (CSN) は,CRL4A ((DDB2) のようなクリンリングリガゼ (CRLs) を誘導適合メカニズムで活性化させ,DNA修復のためのCRLファミリー全体で保存された規制原理を明らかにする.

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