ゼブラフィッシュの2つの背面ヘブンヌラサブリージョンによって調整される社会的紛争の解決

Ming-Yi Chou¹, Ryunosuke Amo¹, Masae Kinoshita¹

¹Laboratory for Developmental Gene Regulation, RIKEN Brain Science Institute, Saitama 351-0198, Japan.

Science (New York, N.Y.)

|April 2, 2016

まとめ

ゼブラフィッシュの社会的階層は2つの背面ヘブンヌラ (dHb) 準領域によって規制されています. dHbLは敗北を促し dHbMは勝利を促し攻撃性の二重制御システムを明らかにします

科学分野:

神経科学
エトロジー
行動生物学

背景:

社会的階層は攻撃的な動物との出会いによって確立され維持されます
紛争解決と社会的階層決定の神経的基盤は十分に理解されていません

研究の目的:

ゼブラフィッシュの戦闘行動の解明を制御する神経機構を調査する
社会的葛藤の結果を決定する脳の特定の領域を特定する

主な方法:

ゼブラフィッシュをモデル生物として利用し社会的攻撃性を研究しました
紛争後の特定の脳回路における神経伝達変化を調査した.
背面ヘブンヌラ (dHb) 亜領域 (dHbLとdHbM) の活動を操作して,戦闘行動への影響を観察した.

主要な成果:

衝突の結果を敵対的に調節する背面ヘブンヌラ (dHb) の2つのサブ領域を特定した.
dHb (dHbL) - 背中/中間のインターペデュキュラ核 (d/iIPN) 回路の横側サブ領域での神経伝播を減少させた.
dHbLを静止すると負ける可能性が高くなり dHbMを静止すると勝つ可能性が高くなります

結論:

dHbLとdHbMは社会的攻撃を解決するための二重制御システムとして機能します
これらの発見は紛争を通じて社会階層の確立に関与する重要な神経回路を明らかにしています

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