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関連する概念動画

Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Network Function of a Circuit

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Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

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遺伝子回路設計の自動化

Alec A K Nielsen1, Bryan S Der2, Jonghyeon Shin1

  • 1Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Science (New York, N.Y.)
|April 2, 2016
PubMed
まとめ
この要約は機械生成です。

DNAでコード化された 遺伝子回路の設計環境を 開発しました この自動化は,生物技術の応用のための複雑な生物回路の作成を簡素化し,意思決定と制御を改善します.

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Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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Automated Robotic Liquid Handling Assembly of Modular DNA Devices
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科学分野:

  • 合成生物学
  • コンピュータ生物学
  • 分子工学

背景:

  • 生きている細胞は DNAでコード化された回路を使って 計算を行うことができます
  • これらの回路の構築は,手作業の組み立てと表現バランスにより,現在時間がかかります.

研究 の 目的:

  • DNAでコードされた遺伝子回路の作成を 自動化する設計環境のCelloを紹介します
  • 生物技術における遺伝子回路の設計プロセスを簡素化し,加速する.

主な方法:

  • ユーザはVerilogのコードを書き セルロはDNAの配列に変換します
  • アルゴリズムは回路設計,ゲート割り当て,接続,パフォーマンスシミュレーションを処理します.
  • 遺伝子回路の設計はEscherichia coliでテストされました.

主要な成果:

  • セルロはエシェリキア・コライの 60の遺伝子回路を 設計することに成功しました
  • 設計された60回路のうち45回がすべての出力状態で正しく実行された.
  • すべての設計された出力状態の92%がソフトウェアによって予測されたように機能した.

結論:

  • セルロース設計の自動化は 遺伝子回路をバイオテクノロジーに組み込むことを簡素化します
  • このアプローチは,生物学的システムにおける意思決定,制御,感知,空間的組織を必要とするアプリケーションを容易にする.