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Updated: Mar 23, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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人間のセロトニントランスポーターのX線構造とメカニズム

Jonathan A Coleman1, Evan M Green1, Eric Gouaux1,2

  • 1Vollum Institute, Oregon Health &Science University, Portland, Oregon 97239, USA.

Nature
|April 7, 2016
PubMed
まとめ

セロトニントランスポーター (SERT) の構造的な洞察は, (S) - シタロプラムとパロキセチンのような抗うつ薬がどのように結合するかを明らかにします. これらの薬は,SERTを外側に開いた状態に閉じることで,セロトニンの再吸収を阻害し,将来の抗うつ薬の設計に情報を与えます.

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