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Updated: Mar 23, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination

Published on: January 2, 2026

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E1およびE2酵素から独立してバクテリアエフェクターによるユビキチン化

Jiazhang Qiu1, Michael J Sheedlo2, Kaiwen Yu3

  • 1Purdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

Nature
|April 7, 2016
PubMed
まとめ

Legionella pneumophilaのような細菌の病原体は新しい酵素を用いて宿主タンパク質を ubiquitinateする. このプロセスは従来のE1/E2酵素を回避し,ユビキチン活性化にはニコチナミドアデニンジヌクレオチドのみが必要です.

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